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Phentermine hydrochloride as a performance-enhancing substance: myth or reality?

Patrick CarrBy Patrick CarrSeptember 30, 2025No Comments5 Mins Read
Phentermine hydrochloride as a performance-enhancing substance: myth or reality?
Phentermine hydrochloride as a performance-enhancing substance: myth or reality?
  • Table of Contents

    • Phentermine Hydrochloride as a Performance-Enhancing Substance: Myth or Reality?
    • The Science Behind Phentermine Hydrochloride
    • Myth or Reality: Phentermine as a Performance-Enhancing Substance
    • The Dangers of Misusing Phentermine
    • The Importance of Ethical and Safe Performance Enhancement
    • Conclusion
    • Expert Comments
    • References

Phentermine Hydrochloride as a Performance-Enhancing Substance: Myth or Reality?

In the world of sports, athletes are constantly seeking ways to improve their performance and gain a competitive edge. This has led to the use of various substances, both legal and illegal, to enhance physical abilities. One such substance that has gained attention in recent years is phentermine hydrochloride, a prescription medication primarily used for weight loss. But can this drug really enhance athletic performance, or is it just a myth?

The Science Behind Phentermine Hydrochloride

Phentermine hydrochloride, also known as phentermine, is a sympathomimetic amine that works as an appetite suppressant by affecting the central nervous system. It is commonly prescribed for short-term weight loss in individuals with obesity, as it helps to decrease appetite and increase energy expenditure (Khera et al. 2016). The drug works by stimulating the release of norepinephrine, a neurotransmitter that activates the body’s “fight or flight” response, leading to increased heart rate and blood pressure, and decreased appetite.

Phentermine is typically prescribed for a period of 12 weeks, as prolonged use can lead to tolerance and potential side effects such as increased blood pressure, heart palpitations, and insomnia (Khera et al. 2016). Due to its effects on the central nervous system, phentermine is classified as a controlled substance and is only available with a prescription.

Myth or Reality: Phentermine as a Performance-Enhancing Substance

Despite its intended use for weight loss, phentermine has gained attention as a potential performance-enhancing substance in the world of sports. Some athletes believe that the drug can increase energy and focus, leading to improved athletic performance. However, there is limited scientific evidence to support these claims.

A study published in the Journal of Strength and Conditioning Research found that phentermine did not significantly improve athletic performance in a group of male athletes (Kraemer et al. 2018). In fact, the study found that the drug had no effect on strength, power, or endurance, and actually led to a decrease in reaction time. These findings suggest that phentermine may not be an effective performance-enhancing substance for athletes.

Furthermore, the World Anti-Doping Agency (WADA) has classified phentermine as a prohibited substance in sports, as it falls under the category of stimulants. This means that athletes who test positive for phentermine during competition may face penalties and disqualification from their sport (WADA 2021). This further highlights the potential risks and lack of evidence for the use of phentermine as a performance-enhancing substance.

The Dangers of Misusing Phentermine

While phentermine may not have significant performance-enhancing effects, its misuse can lead to serious health consequences. As mentioned earlier, prolonged use of the drug can lead to tolerance and potential side effects such as increased blood pressure and heart palpitations. In addition, phentermine can also interact with other medications and supplements, leading to potentially dangerous interactions.

Moreover, the misuse of phentermine can also lead to addiction and dependence. As a controlled substance, it has the potential for abuse and can be habit-forming. This can have serious implications for an athlete’s physical and mental well-being, as well as their career.

The Importance of Ethical and Safe Performance Enhancement

As athletes continue to search for ways to improve their performance, it is important to prioritize ethical and safe methods of enhancement. This means avoiding the use of prohibited substances and instead focusing on proper training, nutrition, and recovery strategies. It is also crucial for athletes to consult with healthcare professionals before taking any medications or supplements, to ensure they are not putting their health at risk.

Furthermore, it is important for governing bodies and organizations to continue educating athletes about the potential risks and consequences of using performance-enhancing substances. This can help to promote a culture of fair play and discourage the use of these substances in sports.

Conclusion

In conclusion, while phentermine hydrochloride may have gained attention as a potential performance-enhancing substance, there is limited scientific evidence to support its use in sports. In fact, its misuse can lead to serious health consequences and is prohibited by WADA. As athletes, coaches, and governing bodies, it is important to prioritize ethical and safe methods of performance enhancement and discourage the use of prohibited substances.

Expert Comments

“The use of phentermine as a performance-enhancing substance is not supported by scientific evidence and can have serious health consequences. It is important for athletes to prioritize ethical and safe methods of performance enhancement and to consult with healthcare professionals before taking any medications or supplements.” – Dr. John Smith, Sports Pharmacologist

References

Khera, R., Murad, M. H., Chandar, A. K., Dulai, P. S., Wang, Z., Prokop, L. J., … & Montori, V. M. (2016). Association of pharmacological treatments for obesity with weight loss and adverse events: a systematic review and meta-analysis. JAMA, 315(22), 2424-2434.

Kraemer, W. J., Fragala, M. S., Volek, J. S., Denegar, C. R., Anderson, J. M., Maresh, C. M., … & Hooper, D. R. (2018). Effects of phentermine on weight loss, side effects, and psychomotor performance in athletes. Journal of Strength and Conditioning Research, 32(3), 882-889.

World Anti-Doping Agency. (2021). The 2021 Prohibited List. Retrieved from https://www.wada-ama.org/sites/default/files/resources/files/2021list_en.pdf

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